Precision Medicine · Healthcare AI · Agentic Systems

Swaminathan
Rajagopalan

Senior Director of Engineering — building trustworthy clinical AI at scale.

Precision Medicine & Healthcare AI · GenAI · LLMs · RAG · Agentic AI · Computational Biology · Oncology

Cellworks Group Inc. · Palo Alto / San Francisco, CA

Experience19+ years
Teams Built100+ members
Peer-Reviewed25+ publications
Conference Output125+ presentations
Intellectual PropertyWIPO patent
Turning cutting-edge biology into clinical-grade AI

I build AI systems that help oncologists make better treatment decisions — and I've spent 19 years turning cutting-edge computational biology into clinical-grade platforms that doctors depend on.

As Senior Director of Engineering at Cellworks, I lead the engineering behind the Singula™ precision-oncology platforms — architecting the workflows and cloud infrastructure that turn a genome-scale biosimulation engine (the Computational Omics Biology Model: 6,000+ genes, 30,000+ molecular species, 600,000+ interactions) into clinically deployable products, and directing cross-functional teams across computational biology, AI/ML, and cloud to get there.

My work lives at the intersection of three worlds most people keep separate:

AI & GenAI

Agentic AI orchestration, RAG pipelines, fine-tuned oncology LLMs (LoRA/QLoRA), knowledge-graph grounding & hallucination mitigation to clinical evidential standards.

HPC & Cloud

HIPAA-compliant AWS platforms (EC2, SageMaker, Bedrock, Lambda) running millions of concurrent biosimulations on thousands of patient genomes.

Clinical & Regulatory

CLIA, ISO 13485, FDA audit readiness & validated SDLC, plus forward-deployed delivery inside hospital EHR environments.

Multi-Omic NGS Input CBM Engine 6,000+ genes 600K+ interactions TRI Score 0 – 100 Singula™ Singula Lung™ Ventura™ AWS HPC · HIPAA · CLIA · ISO 13485 · Validated SDLC
Core Domains
Healthcare AI Agentic AI · RAG · LLMs Computational Biology Cloud (AWS) · HPC Precision Medicine HIPAA · FDA · CLIA
Professional Experience
Nearly two decades building Cellworks' precision-medicine platform — from foundational computational science to engineering leadership.
Apr 2025 — Present
Senior Director of Engineering
Cellworks Group Inc.
South San Francisco, CA
AI/GenAI roadmap — agentic orchestration, RAG, fine-tuned clinical LLMs Scaling a cross-functional engineering organization Partnering with CEO & board on AI strategy HIPAA-compliant, FDA audit-ready platform delivery Trustworthy-AI: grounding, evaluation, hallucination mitigation
Oct 2019 — Mar 2025
Director of Engineering
Cellworks Group Inc.
South San Francisco, CA
Architected Singula™ platform & engineering workflows Agentic AI + RAG pipelines with fine-tuned oncology LLMs HIPAA-compliant AWS HPC — millions of concurrent biosimulations M&A technical integration of an acquired clinical-AI company Cardiovascular risk-scoring portfolio expansion CLIA lab · ISO 13485 · FDA audit readiness · Validated SDLC 25+ peer-reviewed publications · 125+ conference presentations
Nov 2011 — Sep 2019
Engineering Manager
Cellworks Research
Bengaluru, India
HPC biosimulation workflow — NGS · aCGH · RNA-seq · microarray AI knowledge-acquisition engine (NLP · ML · graph reasoning) AWS auto-scaling compute for concurrent biosimulations Matured the engine from prototype to clinical-grade platform Agile delivery · code-review standards · quality gates
2003 — 2011
Earlier Roles
Cellworks · CSIR-IGIB · Bharath University
Lead Computational Scientist — biosimulation engine architecture ODE solvers: Euler · Dormand–Prince · RADAU II-A · CPU/GPU HPC Associate Bio-modeling Scientist Lecturer, Bioinformatics — Bharath University (2004–2006) Research Associate — IGIB (CSIR), New Delhi · PDB 1VZN (2003–2004)
Technical Expertise
From foundation-model engineering to regulated clinical deployment.

GenAI & Agentic Systems

Agentic AIMulti-Agent SystemsRAG PipelinesFine-Tuning (LoRA/QLoRA)Clinical LLMsKnowledge-Graph GroundingLangChainLlamaIndexOpenAI APIClaude APIAWS BedrockAzure OpenAIPrompt EngineeringFAISSPineconeVector DBs

Machine Learning

PyTorchTensorFlowKerasScikit-learnXGBoostLightGBMHugging FaceMLflowW&BONNXSurvival Analysis

Cloud & Infrastructure

AWS EC2S3LambdaSageMakerBedrockIAMDatabricksDockerMicroservicesAzure

Programming & Data

PythonC/C++RTCLPerlMySQLMongoDBGitSAS 9.4

Biosimulation & HPC

ODE SolversEuler/DP5/RADAUGPU ComputingPathway ModelingEnzyme KineticsCBMMulti-omics

Regulatory & Practices

HIPAACLIAISO 13485FDA Audit ReadinessValidated SDLCAgileCI/CDOKRs
Publications & Clinical Studies
Co-author of 25+ peer-reviewed publications across high-impact oncology journals, with 125+ presentations alongside global collaborators at ASCO, ASH, WCLC & ASTRO.
Featured · JCO

Superior OS, PFS & CR predictions for NSCLC using Cellworks Singula — myCare-022-05

Journal of Clinical Oncology (ASCO Annual Meeting) · biosimulation-guided therapy prediction in non-small cell lung cancer.

25+ peer-reviewed publications · 125+ conference presentations Full list on LinkedIn → ResearchGate →
Institutional Research Partners
Sustained research partnerships with NCI-designated cancer centers, academic medical schools & integrated health systems across North America and Europe.
Dana-Farber Cancer Institute Harvard Medical School Mayo Clinic Cleveland Clinic Veterans Affairs (VA) University of Nebraska Cambridge University Miami Cancer Institute University of Pennsylvania NYU Grossman School of Medicine
Patent & Projects
Published Patent · WIPO

System and Method for Development of Therapeutic Solutions

WO/2014/072950 · PCT/IB2013/060011 · Named inventor

Foundational IP underpinning Cellworks' biosimulation methodology and precision-medicine approach — a computational framework for developing patient-specific therapeutic solutions.

View on Google Patents
Personal AI Project · 2025

Enterprise Agentic AI Solution

A proprietary enterprise agentic-AI system built to compress time-to-insight in high-stakes, regulated workflows — combining agent orchestration, RAG, and knowledge-graph grounding. Currently in evaluation with enterprise partners.

Academic Background
M.Tech, Bioinformatics
SASTRA University, India · 2002–2004
CGPA 8.27 / 10University 1st Rank — Genomics & Proteomics
B.E., Chemical Engineering
Annamalai University, India · 1997–2001
First Class
Honors & Achievements

PDB Structure Deposit

Deposited the HPV E6 oncoprotein 3D structure in the Protein Data Bank — PDB ID 1VZN.

University 1st Rank

1st Rank in Genomics & Proteomics, M.Tech Bioinformatics — SASTRA University.

3× Project Management Award

Recognized three times with the Outstanding Project Management Award.

Best Teacher Award

"Best Teacher 2005–2006" — Lecturer in Bioinformatics, Bharath University, Chennai.

Foundational Algorithms

Authored the core computational-biology algorithms powering the biosimulation platform.

Multi-Cancer Validation

Platform validated across AML, MDS, NSCLC, GBM, ESAD, PDAC & ETP-ALL indications.

Let's build trustworthy AI together

Palo Alto, California